When a doctor prescribes a drug for a condition which it has not been
approved for, this is known as off-label drug use. Around the world,
off-label use is an accepted and common practice, especially in certain
medical disciplines. At times, off-label use represents an innovative and
fresh approach to a condition

The San Andreas Fault is a major geologic fault which runs along the coast
of Northern California, veering inland as it approaches Southern
California. Because the fault runs along heavily populated regions of the
state, it is often a topic of discussion, as a major earthquake on the San
Andreas Fault could be a very serious problem for California. The San
Francisco Earthquake of 1906